Tylenol with Codeine, Tylenol #3 (codeine/acetaminophen) dosing, indications, interactions, adverse effects, and more (2023)

  • benzhydrocodone/acetaminophen

    benzhydrocodone/acetaminophen, codeine.Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

  • bremelanotide

    bremelanotide will decrease the level or effect of codeine by Other (see comment). Avoid or Use Alternate Drug. Bremelanotide may slow gastric emptying and potentially reduces the rate and extent of absorption of concomitantly administered oral medications. Avoid use when taking any oral drug that is dependent on threshold concentrations for efficacy. Interactions listed are representative examples and do not include all possible clinical examples.

  • buprenorphine

    buprenorphine, codeine. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.

  • buprenorphine buccal

    buprenorphine buccal, codeine. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.

  • butorphanol

    butorphanol, codeine. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.

  • calcium/magnesium/potassium/sodium oxybates

    codeine, calcium/magnesium/potassium/sodium oxybates.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

  • clonidine

    clonidine, codeine.Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration enhances CNS depressant effects.

  • dacomitinib

    dacomitinib will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid use with CYP2D6 substrates where minimal increases in concentration of the CYP2D6 substrate may lead to serious or life-threatening toxicities.

  • diazepam intranasal

    diazepam intranasal, codeine.Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

  • eluxadoline

    codeine, eluxadoline.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that cause constipation. Increases risk for constipation related serious adverse reactions. .

  • fentanyl

    fentanyl, codeine.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.

  • fentanyl intranasal

    fentanyl intranasal, codeine.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.

  • fentanyl transdermal

    fentanyl transdermal, codeine.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.

  • fentanyl transmucosal

    fentanyl transmucosal, codeine.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.

  • givosiran

    givosiran will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP2D6 substrates with givosiran. If unavoidable, decrease the CYP2D6 substrate dosage in accordance with approved product labeling.

  • hydrocodone

    hydrocodone, codeine.Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

  • isocarboxazid

    isocarboxazid increases toxicity of codeine by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.

  • linezolid

    linezolid increases toxicity of codeine by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.

  • lonafarnib

    acetaminophen will increase the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If coadministration of lonafarnib (a sensitive CYP3A substrate) with weak CYP3A inhibitors is unavoidable, reduce to, or continue lonafarnib at starting dose. Closely monitor for arrhythmias and events (eg, syncope, heart palpitations) since lonafarnib effect on QT interval is unknown.

  • methylene blue

    methylene blue and codeine both increase serotonin levels. Avoid or Use Alternate Drug. If drug combination must be administered, monitor for evidence of serotonergic or opioid-related toxicities

  • metoclopramide intranasal

    codeine, metoclopramide intranasal.Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.

  • nalbuphine

    nalbuphine, codeine. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.

  • ozanimod

    ozanimod and codeine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Avoid or Use Alternate Drug. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. Monitor for hypertension with concomitant use.

  • pentazocine

    pentazocine, codeine. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.

  • pexidartinib

    acetaminophen and pexidartinib both increase Other (see comment). Avoid or Use Alternate Drug. Pexidartinib can cause hepatotoxicity. Avoid coadministration of pexidartinib with other products know to cause hepatoxicity.

  • phenelzine

    phenelzine increases toxicity of codeine by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.

  • prasugrel

    codeine will decrease the level or effect of prasugrel by inhibition of GI absorption. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Co-administration of opioid agonists delay and reduce absorption of prasugrel and its active metabolite presumably by slowing gastric emptying; consider the use of a parenteral anti-platelet agent in acute coronary syndrome patients requiring co-administration of opioid agonists

  • pretomanid

    acetaminophen, pretomanid.Either increases toxicity of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Pretomanid regimen associated with hepatotoxicity. Avoid alcohol and hepatotoxic agents, including herbal supplements and drugs other than bedaquiline and linezolid.

  • procarbazine

    procarbazine increases toxicity of codeine by unknown mechanism. Avoid or Use Alternate Drug. MAOIs may potentiate CNS depression and hypotension. Do not use within 14 days of MAOI use. .

  • abiraterone

    abiraterone increases levels of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Avoid coadministration of abiraterone with substrates of CYP2D6. If alternative therapy cannot be used, exercise caution and consider a dose reduction of the CYP2D6 substrate.

  • albuterol

    codeine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • alfentanil

    alfentanil and codeine both increase sedation. Use Caution/Monitor.

  • alprazolam

    alprazolam and codeine both increase sedation. Use Caution/Monitor.

  • amiodarone

    amiodarone will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • amitriptyline

    codeine and amitriptyline both increase sedation. Use Caution/Monitor.

  • amobarbital

    amobarbital and codeine both increase sedation. Use Caution/Monitor.

  • amoxapine

    codeine and amoxapine both increase sedation. Use Caution/Monitor.

  • apalutamide

    apalutamide will decrease the level or effect of acetaminophen by increasing elimination. Use Caution/Monitor. Apalutamide induces UGT and may decrease systemic exposure of drugs that are UGT substrates.

  • apomorphine

    codeine and apomorphine both increase sedation. Use Caution/Monitor.

  • arformoterol

    codeine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • aripiprazole

    codeine and aripiprazole both increase sedation. Use Caution/Monitor.

  • armodafinil

    codeine increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • artemether/lumefantrine

    artemether/lumefantrine will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • atogepant

    acetaminophen will increase the level or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

  • avapritinib

    acetaminophen will increase the level or effect of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

  • axitinib

    acetaminophen increases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

  • azelastine

    azelastine and codeine both increase sedation. Use Caution/Monitor.

  • baclofen

    baclofen and codeine both increase sedation. Use Caution/Monitor.

  • belladonna and opium

    codeine and belladonna and opium both increase sedation. Use Caution/Monitor.

  • benperidol

    codeine and benperidol both increase sedation. Use Caution/Monitor.

  • benzphetamine

    codeine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • brexanolone

    brexanolone, codeine.Either increases toxicity of the other by sedation. Use Caution/Monitor.

  • brompheniramine

    brompheniramine and codeine both increase sedation. Use Caution/Monitor.

  • bupivacaine implant

    acetaminophen, bupivacaine implant.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Local anesthetics may increase the risk of developing methemoglobinemia when concurrently exposed to drugs that also cause methemoglobinemia.

  • buprenorphine

    buprenorphine and codeine both increase sedation. Use Caution/Monitor.

  • buprenorphine buccal

    buprenorphine buccal and codeine both increase sedation. Use Caution/Monitor.

  • buprenorphine, long-acting injection

    codeine increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.

  • bupropion

    bupropion will decrease the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents the conversion of codeine to its active metabolite morphine.

  • busulfan

    acetaminophen increases levels of busulfan by decreasing metabolism. Use Caution/Monitor. Use of acetaminophen prior to (< 72 hours) or concurrently with busulfan may result in decreased clearance of busulfan due to acetaminophen-induced decreases in glutathione levels.

  • butabarbital

    butabarbital and codeine both increase sedation. Use Caution/Monitor.

  • butalbital

    butalbital and codeine both increase sedation. Use Caution/Monitor.

  • butorphanol

    butorphanol and codeine both increase sedation. Use Caution/Monitor.

  • caffeine

    codeine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • carbinoxamine

    carbinoxamine and codeine both increase sedation. Use Caution/Monitor.

  • carisoprodol

    carisoprodol and codeine both increase sedation. Use Caution/Monitor.

  • celecoxib

    celecoxib decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • cenobamate

    cenobamate, codeine.Either increases effects of the other by sedation. Use Caution/Monitor.

  • chloral hydrate

    chloral hydrate and codeine both increase sedation. Use Caution/Monitor.

    (Video) Acetaminophen & Codeine (Tylenol 3/4) Patient Counseling

  • chlordiazepoxide

    chlordiazepoxide and codeine both increase sedation. Use Caution/Monitor.

  • chloroquine

    chloroquine will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • chlorpheniramine

    chlorpheniramine and codeine both increase sedation. Use Caution/Monitor.

  • chlorpromazine

    codeine and chlorpromazine both increase sedation. Use Caution/Monitor.chlorpromazine will decrease the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine

  • chlorzoxazone

    chlorzoxazone and codeine both increase sedation. Use Caution/Monitor.

  • cimetidine

    cimetidine will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • cinacalcet

    cinacalcet decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • cinnarizine

    cinnarizine and codeine both increase sedation. Use Caution/Monitor.

  • clemastine

    clemastine and codeine both increase sedation. Use Caution/Monitor.

  • clobazam

    codeine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).clobazam decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • clomipramine

    codeine and clomipramine both increase sedation. Use Caution/Monitor.clomipramine decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • clonazepam

    clonazepam and codeine both increase sedation. Use Caution/Monitor.

  • clorazepate

    clorazepate and codeine both increase sedation. Use Caution/Monitor.

  • clozapine

    codeine and clozapine both increase sedation. Use Caution/Monitor.clozapine decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • cocaine topical

    cocaine topical decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • cyclizine

    cyclizine and codeine both increase sedation. Use Caution/Monitor.

  • cyclobenzaprine

    cyclobenzaprine and codeine both increase sedation. Use Caution/Monitor.

  • cyproheptadine

    cyproheptadine and codeine both increase sedation. Use Caution/Monitor.

  • dantrolene

    dantrolene and codeine both increase sedation. Use Caution/Monitor.

  • dapsone topical

    acetaminophen increases toxicity of dapsone topical by altering metabolism. Modify Therapy/Monitor Closely. May induce methemoglobinemia .

  • daridorexant

    codeine and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.

  • darifenacin

    darifenacin decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • desflurane

    desflurane and codeine both increase sedation. Use Caution/Monitor. Opioids may decrease MAC requirements, less inhalation anesthetic may be required.

  • desipramine

    codeine and desipramine both increase sedation. Use Caution/Monitor.desipramine decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • desvenlafaxine

    desvenlafaxine will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by up to 50%; no dosage adjustment needed with desvenlafaxine doses <100 mg

  • deutetrabenazine

    codeine and deutetrabenazine both increase sedation. Use Caution/Monitor.

  • dexchlorpheniramine

    dexchlorpheniramine and codeine both increase sedation. Use Caution/Monitor.

  • dexfenfluramine

    codeine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • dexmedetomidine

    dexmedetomidine and codeine both increase sedation. Use Caution/Monitor.

  • dexmethylphenidate

    codeine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • dextroamphetamine

    codeine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • dextromoramide

    codeine and dextromoramide both increase sedation. Use Caution/Monitor.

  • diamorphine

    codeine and diamorphine both increase sedation. Use Caution/Monitor.

  • diazepam

    diazepam and codeine both increase sedation. Use Caution/Monitor.

  • diethylpropion

    codeine increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • difelikefalin

    difelikefalin and codeine both increase sedation. Use Caution/Monitor.

  • difenoxin hcl

    codeine and difenoxin hcl both increase sedation. Use Caution/Monitor.

  • dimenhydrinate

    dimenhydrinate and codeine both increase sedation. Use Caution/Monitor.

  • diphenhydramine

    diphenhydramine decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.diphenhydramine and codeine both increase sedation. Use Caution/Monitor.

  • diphenoxylate hcl

    codeine and diphenoxylate hcl both increase sedation. Use Caution/Monitor.

  • dipipanone

    codeine and dipipanone both increase sedation. Use Caution/Monitor.

  • dobutamine

    codeine increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • dopamine

    codeine increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • dopexamine

    codeine increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • dosulepin

    codeine and dosulepin both increase sedation. Use Caution/Monitor.

  • doxepin

    codeine and doxepin both increase sedation. Use Caution/Monitor.

  • doxylamine

    doxylamine and codeine both increase sedation. Use Caution/Monitor.

  • dronedarone

    dronedarone decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • droperidol

    codeine and droperidol both increase sedation. Use Caution/Monitor.

  • duloxetine

    duloxetine decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • eltrombopag

    eltrombopag increases levels of acetaminophen by decreasing metabolism. Use Caution/Monitor. UGT inhibition; significance of interaction unclear.

  • elvitegravir/cobicistat/emtricitabine/tenofovir DF

    elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of codeine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Cobicistat is a CYP2D6 inhibitor; caution with CYP2D6 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events.

  • ephedrine

    codeine increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • epinephrine

    codeine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • epinephrine racemic

    codeine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • esketamine intranasal

    esketamine intranasal, codeine.Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.

  • estazolam

    estazolam and codeine both increase sedation. Use Caution/Monitor.

  • ethanol

    codeine and ethanol both increase sedation. Use Caution/Monitor.

  • etomidate

    etomidate and codeine both increase sedation. Use Caution/Monitor.

  • exenatide injectable solution

    exenatide injectable solution will decrease the level or effect of acetaminophen by unspecified interaction mechanism. Use Caution/Monitor. To avoid potential interaction, give acetaminophen at least 1 hour before or 4 hours after exenatide injection.

  • exenatide injectable suspension

    exenatide injectable suspension will decrease the level or effect of acetaminophen by unspecified interaction mechanism. Use Caution/Monitor. To avoid potential interaction, give acetaminophen at least 1 hour before or 4 hours after exenatide injection.

  • fedratinib

    fedratinib will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Adjust dose of drugs that are CYP2D6 substrates as necessary.

  • fenfluramine

    codeine increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • finerenone

    acetaminophen will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Monitor serum potassium during initiation and dosage adjustment of either finererone or moderate CYP3A4 inhibitors. Adjust finererone dosage as needed.

  • flibanserin

    codeine and flibanserin both increase sedation. Modify Therapy/Monitor Closely. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.acetaminophen will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Increased flibanserin adverse effects may occur if coadministered with multiple weak CYP3A4 inhibitors.

  • fluoxetine

    fluoxetine will decrease the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine

  • imatinib

    imatinib decreases levels of acetaminophen by decreasing hepatic clearance. Modify Therapy/Monitor Closely. In vitro, imatinib was found to inhibit acetaminophen O-glucuronidation (Ki value of 58.5 micro-M) at therapeutic levels; avoid chronic acetaminophen therapy with imatinib; if occasional acetaminophen administered, do not exceed 1300 mg/day.

  • fluphenazine

    codeine and fluphenazine both increase sedation. Use Caution/Monitor.

  • flurazepam

    flurazepam and codeine both increase sedation. Use Caution/Monitor.

    (Video) NCLEX Prep (Pharmacology): Codeine/Acetaminophen (Tylenol 3)

  • formoterol

    codeine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • gabapentin

    gabapentin, codeine.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

  • gabapentin enacarbil

    gabapentin enacarbil, codeine.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

  • ganaxolone

    codeine and ganaxolone both increase sedation. Use Caution/Monitor.

  • haloperidol

    haloperidol decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.codeine and haloperidol both increase sedation. Use Caution/Monitor.

  • hydromorphone

    codeine and hydromorphone both increase sedation. Use Caution/Monitor.

  • hydroxyzine

    hydroxyzine and codeine both increase sedation. Use Caution/Monitor.

  • iloperidone

    codeine and iloperidone both increase sedation. Use Caution/Monitor.

  • imipramine

    codeine and imipramine both increase sedation. Use Caution/Monitor.imipramine decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • isavuconazonium sulfate

    acetaminophen will increase the level or effect of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

  • isoniazid

    isoniazid will increase the level or effect of acetaminophen by affecting hepatic enzyme CYP2E1 metabolism. Use Caution/Monitor.isoniazid decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • isoproterenol

    codeine increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • ivacaftor

    acetaminophen increases levels of ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor when coadministered with weak CYP3A4 inhibitors .

  • ketamine

    ketamine and codeine both increase sedation. Use Caution/Monitor.

  • ketoconazole

    ketoconazole decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • ketotifen, ophthalmic

    codeine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

  • lasmiditan

    lasmiditan, codeine.Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.

  • lemborexant

    lemborexant, codeine.Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.acetaminophen will increase the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Lower nightly dose of lemborexant recommended if coadministered with weak CYP3A4 inhibitors. See drug monograph for specific dosage modification.

  • letermovir

    letermovir increases levels of codeine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

  • levonorgestrel oral/ethinylestradiol/ferrous bisglycinate

    levonorgestrel oral/ethinylestradiol/ferrous bisglycinate will decrease the level or effect of acetaminophen by unknown mechanism. Use Caution/Monitor.acetaminophen increases levels of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by decreasing hepatic clearance. Use Caution/Monitor. Coadministration of ascorbic acid and certain combined hormonal contraceptives (CHCs) containing EE may increase plasma EE concentrations, possibly by inhibition of conjugation.

  • levalbuterol

    codeine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • levoketoconazole

    levoketoconazole decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • levorphanol

    codeine and levorphanol both increase sedation. Use Caution/Monitor.

  • lisdexamfetamine

    codeine increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • lixisenatide

    lixisenatide will decrease the level or effect of acetaminophen by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. GLP1 agonists delay gastric emptying, which may affect absorption of concomitantly administered oral medications. No effects on acetaminophen Cmax and Tmax were observed when acetaminophen was administered 1 hr before lixisenatide. When administered 1 or 4 hr after lixisenatide, acetaminophen Cmax was decreased by 29% and 31% respectively and median Tmax was delayed by 2 and 1.75 hr, respectively.

  • lofepramine

    codeine and lofepramine both increase sedation. Use Caution/Monitor.

  • lofexidine

    codeine and lofexidine both increase sedation. Use Caution/Monitor.

  • lomitapide

    acetaminophen increases levels of lomitapide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Lomitapide dose should not exceed 30 mg/day.

  • lopinavir

    lopinavir decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • loprazolam

    loprazolam and codeine both increase sedation. Use Caution/Monitor.

  • lorazepam

    lorazepam and codeine both increase sedation. Use Caution/Monitor.

  • lorcaserin

    lorcaserin will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • lormetazepam

    lormetazepam and codeine both increase sedation. Use Caution/Monitor.

  • loxapine

    codeine and loxapine both increase sedation. Use Caution/Monitor.

  • loxapine inhaled

    codeine and loxapine inhaled both increase sedation. Use Caution/Monitor.

  • lumefantrine

    lumefantrine will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • lurasidone

    lurasidone, codeine.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.

  • maprotiline

    codeine and maprotiline both increase sedation. Use Caution/Monitor.

  • marijuana

    codeine and marijuana both increase sedation. Use Caution/Monitor.

  • melatonin

    codeine and melatonin both increase sedation. Use Caution/Monitor.

  • meperidine

    codeine and meperidine both increase sedation. Use Caution/Monitor.

  • meprobamate

    codeine and meprobamate both increase sedation. Use Caution/Monitor.

  • metaproterenol

    codeine increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • metaxalone

    metaxalone and codeine both increase sedation. Use Caution/Monitor.

  • methadone

    codeine and methadone both increase sedation. Use Caution/Monitor.

  • methamphetamine

    codeine increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • methocarbamol

    methocarbamol and codeine both increase sedation. Use Caution/Monitor.

  • methylenedioxymethamphetamine

    codeine increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • midazolam

    midazolam and codeine both increase sedation. Use Caution/Monitor.

  • midazolam intranasal

    midazolam intranasal, codeine.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.acetaminophen will increase the level or effect of midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Coadministration of mild CYP3A4 inhibitors with midazolam intranasal may cause higher midazolam systemic exposure, which may prolong sedation.

  • midodrine

    codeine increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • mipomersen

    mipomersen, acetaminophen.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Both drugs have potential to increase hepatic enzymes; monitor LFTs.

  • mirabegron

    mirabegron will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • mirtazapine

    codeine and mirtazapine both increase sedation. Use Caution/Monitor.

  • modafinil

    codeine increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • morphine

    codeine and morphine both increase sedation. Use Caution/Monitor.

  • motherwort

    codeine and motherwort both increase sedation. Use Caution/Monitor.

  • moxonidine

    codeine and moxonidine both increase sedation. Use Caution/Monitor.

  • nabilone

    codeine and nabilone both increase sedation. Use Caution/Monitor.

  • nalbuphine

    codeine and nalbuphine both increase sedation. Use Caution/Monitor.

  • norepinephrine

    codeine increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • nortriptyline

    codeine and nortriptyline both increase sedation. Use Caution/Monitor.

  • olanzapine

    codeine and olanzapine both increase sedation. Use Caution/Monitor.

  • oliceridine

    oliceridine, codeine.Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

  • opium tincture

    codeine and opium tincture both increase sedation. Use Caution/Monitor.

  • orphenadrine

    orphenadrine and codeine both increase sedation. Use Caution/Monitor.

  • oxazepam

    oxazepam and codeine both increase sedation. Use Caution/Monitor.

  • oxycodone

    codeine and oxycodone both increase sedation. Use Caution/Monitor.

  • oxymorphone

    codeine and oxymorphone both increase sedation. Use Caution/Monitor.

    (Video) A Dose of Caution

  • paliperidone

    codeine and paliperidone both increase sedation. Use Caution/Monitor.

  • papaveretum

    codeine and papaveretum both increase sedation. Use Caution/Monitor.

  • papaverine

    codeine and papaverine both increase sedation. Use Caution/Monitor.

  • paroxetine

    paroxetine will decrease the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • peginterferon alfa 2b

    peginterferon alfa 2b, codeine. Other (see comment). Use Caution/Monitor. Comment: When patients are administered peginterferon alpha-2b with CYP2D6 substrates, the therapeutic effect of these drugs may be altered. Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate.

  • pegvisomant

    codeine decreases effects of pegvisomant by unknown mechanism. Use Caution/Monitor.

  • pentazocine

    codeine and pentazocine both increase sedation. Use Caution/Monitor.

  • pentobarbital

    pentobarbital and codeine both increase sedation. Use Caution/Monitor.

  • perampanel

    perampanel and codeine both increase sedation. Use Caution/Monitor.

  • perphenazine

    codeine and perphenazine both increase sedation. Use Caution/Monitor.

  • phendimetrazine

    codeine increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • phenobarbital

    phenobarbital and codeine both increase sedation. Use Caution/Monitor.

  • phentermine

    codeine increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • phenylephrine

    codeine increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • phenylephrine PO

    codeine increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

  • pholcodine

    codeine and pholcodine both increase sedation. Use Caution/Monitor.

  • pimozide

    codeine and pimozide both increase sedation. Use Caution/Monitor.

  • pirbuterol

    codeine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • pregabalin

    pregabalin, codeine.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

  • primidone

    primidone and codeine both increase sedation. Use Caution/Monitor.

  • prochlorperazine

    codeine and prochlorperazine both increase sedation. Use Caution/Monitor.

  • promethazine

    promethazine and codeine both increase sedation. Use Caution/Monitor.

  • propofol

    propofol and codeine both increase sedation. Use Caution/Monitor.

  • propylhexedrine

    codeine increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • protriptyline

    codeine and protriptyline both increase sedation. Use Caution/Monitor.

  • quazepam

    quazepam and codeine both increase sedation. Use Caution/Monitor.

  • quetiapine

    codeine and quetiapine both increase sedation. Use Caution/Monitor.

  • quinidine

    quinidine will decrease the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • ramelteon

    codeine and ramelteon both increase sedation. Use Caution/Monitor.

  • remimazolam

    remimazolam, codeine.Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.

  • ribociclib

    ribociclib will increase the level or effect of codeine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

  • risperidone

    codeine and risperidone both increase sedation. Use Caution/Monitor.

  • ritonavir

    ritonavir will decrease the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • rolapitant

    rolapitant will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Rolapitant may increase plasma concentrations of CYP2D6 substrates for at least 28 days following rolapitant administration.

  • salmeterol

    codeine increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • scullcap

    codeine and scullcap both increase sedation. Use Caution/Monitor.

  • secobarbital

    secobarbital and codeine both increase sedation. Use Caution/Monitor.

  • selegiline

    selegiline increases toxicity of codeine by unknown mechanism. Modify Therapy/Monitor Closely. Potential for increased CNS depression, drowsiness, dizziness or hypotension, so use with any MAOI should be cautious.

  • sertraline

    sertraline decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • sevoflurane

    sevoflurane and codeine both increase sedation. Use Caution/Monitor.

  • shepherd's purse

    codeine and shepherd's purse both increase sedation. Use Caution/Monitor.

  • stiripentol

    stiripentol, codeine.Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.

  • sufentanil

    codeine and sufentanil both increase sedation. Use Caution/Monitor.

  • suvorexant

    suvorexant and codeine both increase sedation. Modify Therapy/Monitor Closely. Dosage adjustments of suvorexant and concomitant CNS depressants may be necessary

  • tapentadol

    codeine and tapentadol both increase sedation. Use Caution/Monitor.

  • tazemetostat

    acetaminophen will increase the level or effect of tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

  • temazepam

    temazepam and codeine both increase sedation. Use Caution/Monitor.

  • terbinafine

    terbinafine will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Assess need to reduce dose of CYP2D6-metabolized drug.

  • terbutaline

    codeine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • tetracaine

    tetracaine, acetaminophen. Other (see comment). Use Caution/Monitor. Comment: Monitor for signs of methemoglobinemia when methemoglobin-inducing drugs are coadministered.

  • thioridazine

    thioridazine decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.codeine and thioridazine both increase sedation. Use Caution/Monitor.

  • thiothixene

    codeine and thiothixene both increase sedation. Use Caution/Monitor.

  • ticlopidine

    ticlopidine decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • tinidazole

    acetaminophen will increase the level or effect of tinidazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

  • topiramate

    codeine and topiramate both increase sedation. Modify Therapy/Monitor Closely.

  • tramadol

    codeine and tramadol both increase sedation. Use Caution/Monitor.

  • tranylcypromine

    tranylcypromine decreases effects of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Prevents conversion of codeine to its active metabolite morphine.

  • trazodone

    codeine and trazodone both increase sedation. Use Caution/Monitor.

  • triazolam

    triazolam and codeine both increase sedation. Use Caution/Monitor.

  • triclofos

    triclofos and codeine both increase sedation. Use Caution/Monitor.

  • trifluoperazine

    codeine and trifluoperazine both increase sedation. Use Caution/Monitor.

  • trimipramine

    codeine and trimipramine both increase sedation. Use Caution/Monitor.

  • triprolidine

    triprolidine and codeine both increase sedation. Use Caution/Monitor.

  • venlafaxine

    venlafaxine will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.

  • warfarin

    acetaminophen increases effects of warfarin by anticoagulation. Use Caution/Monitor.

  • xylometazoline

    codeine increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • acetazolamide

    acetazolamide decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

  • albiglutide

    albiglutide decreases levels of acetaminophen by unspecified interaction mechanism. Minor/Significance Unknown.

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  • antithrombin alfa

    acetaminophen increases effects of antithrombin alfa by unknown mechanism. Minor/Significance Unknown.

  • antithrombin III

    acetaminophen increases effects of antithrombin III by unknown mechanism. Minor/Significance Unknown.

  • argatroban

    acetaminophen increases effects of argatroban by unknown mechanism. Minor/Significance Unknown.

  • asenapine

    asenapine will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.

  • bemiparin

    acetaminophen increases effects of bemiparin by unknown mechanism. Minor/Significance Unknown.

  • bivalirudin

    acetaminophen increases effects of bivalirudin by unknown mechanism. Minor/Significance Unknown.

  • brimonidine

    brimonidine increases effects of codeine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

  • carbamazepine

    carbamazepine decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

  • cholestyramine

    cholestyramine decreases levels of acetaminophen by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

  • clonazepam

    clonazepam decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

  • colestipol

    colestipol decreases levels of acetaminophen by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

  • dalteparin

    acetaminophen increases effects of dalteparin by unknown mechanism. Minor/Significance Unknown.

  • dextroamphetamine

    dextroamphetamine increases effects of codeine by unspecified interaction mechanism. Minor/Significance Unknown.

  • diazepam

    diazepam decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

  • disulfiram

    disulfiram will increase the level or effect of acetaminophen by affecting hepatic enzyme CYP2E1 metabolism. Minor/Significance Unknown.

  • enoxaparin

    acetaminophen increases effects of enoxaparin by unknown mechanism. Minor/Significance Unknown.

  • ethanol

    ethanol will decrease the level or effect of acetaminophen by affecting hepatic enzyme CYP2E1 metabolism. Minor/Significance Unknown.ethanol increases toxicity of acetaminophen by decreasing metabolism. Minor/Significance Unknown.

  • ethosuximide

    ethosuximide decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

  • eucalyptus

    codeine and eucalyptus both increase sedation. Minor/Significance Unknown.

  • felbamate

    felbamate decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

  • fluoxetine

    fluoxetine decreases effects of codeine by decreasing metabolism. Minor/Significance Unknown. Decreased conversion of codeine to active metabolite morphine.

  • fondaparinux

    acetaminophen increases effects of fondaparinux by unknown mechanism. Minor/Significance Unknown.

  • fosphenytoin

    fosphenytoin decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

  • green tea

    green tea increases effects of acetaminophen by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical, due to caffeine content).

  • heparin

    acetaminophen increases effects of heparin by unknown mechanism. Minor/Significance Unknown.

  • imatinib

    imatinib will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.imatinib decreases effects of codeine by decreasing metabolism. Minor/Significance Unknown. Decreased conversion of codeine to active metabolite morphine.

  • isoniazid

    isoniazid increases toxicity of acetaminophen by unknown mechanism. Minor/Significance Unknown.

  • lacosamide

    lacosamide decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

  • lamotrigine

    lamotrigine decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

  • levetiracetam

    levetiracetam decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

  • lidocaine

    lidocaine increases toxicity of codeine by pharmacodynamic synergism. Minor/Significance Unknown. Risk of increased CNS depression.

  • liraglutide

    liraglutide decreases levels of acetaminophen by unspecified interaction mechanism. Minor/Significance Unknown.

  • lorazepam

    lorazepam decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

  • maraviroc

    maraviroc will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.

  • marijuana

    marijuana will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.

  • methsuximide

    methsuximide decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

  • metoclopramide

    metoclopramide increases levels of acetaminophen by enhancing GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

  • metronidazole

    metronidazole will increase the level or effect of acetaminophen by affecting hepatic enzyme CYP2E1 metabolism. Minor/Significance Unknown.

  • nilotinib

    nilotinib will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.

  • oxcarbazepine

    oxcarbazepine decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

  • oxybutynin

    oxybutynin decreases levels of acetaminophen by unspecified interaction mechanism. Minor/Significance Unknown.

  • oxybutynin topical

    oxybutynin topical decreases levels of acetaminophen by unspecified interaction mechanism. Minor/Significance Unknown.

  • oxybutynin transdermal

    oxybutynin transdermal decreases levels of acetaminophen by unspecified interaction mechanism. Minor/Significance Unknown.

  • parecoxib

    parecoxib will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.

  • perphenazine

    perphenazine will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.perphenazine decreases effects of codeine by decreasing metabolism. Minor/Significance Unknown. Decreased conversion of codeine to active metabolite morphine.

  • phenindione

    acetaminophen increases effects of phenindione by unknown mechanism. Minor/Significance Unknown.

  • phenobarbital

    phenobarbital decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

  • phenytoin

    phenytoin decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

  • primidone

    primidone decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

  • propafenone

    propafenone will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.propafenone decreases effects of codeine by decreasing metabolism. Minor/Significance Unknown. Decreased conversion of codeine to active metabolite morphine.

  • protamine

    acetaminophen increases effects of protamine by unknown mechanism. Minor/Significance Unknown.

  • quinacrine

    quinacrine will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.quinacrine decreases effects of codeine by decreasing metabolism. Minor/Significance Unknown. Decreased conversion of codeine to active metabolite morphine.

  • ranolazine

    ranolazine will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.

  • rifabutin

    rifabutin decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

  • rifampin

    rifampin decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

  • rufinamide

    rufinamide decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

  • ruxolitinib

    acetaminophen will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.

  • ruxolitinib topical

    acetaminophen will increase the level or effect of ruxolitinib topical by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.

  • sage

    codeine and sage both increase sedation. Minor/Significance Unknown.

  • sertraline

    sertraline decreases effects of codeine by decreasing metabolism. Minor/Significance Unknown. Decreased conversion of codeine to active metabolite morphine.

  • thioridazine

    thioridazine decreases effects of codeine by decreasing metabolism. Minor/Significance Unknown. Decreased conversion of codeine to active metabolite morphine.

  • tiagabine

    tiagabine decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

  • tipranavir

    tipranavir will increase the level or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown.

  • topiramate

    topiramate decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

  • valproic acid

    valproic acid decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

  • venlafaxine

    venlafaxine decreases effects of codeine by decreasing metabolism. Minor/Significance Unknown. Decreased conversion of codeine to active metabolite morphine.

  • ziconotide

    ziconotide, codeine. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Additive decreased GI motility. Additive analgesia. Ziconotide does NOT potentiate opioid induced respiratory depression.

  • zonisamide

    zonisamide decreases levels of acetaminophen by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism increase levels of hepatotoxic metabolites.

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